ʻO Sesamol

ʻO Sesamol ka lehu Kaʻike Base

inoa	Pauka sesamol
Hoʻolaha	ʻO ka pauma
Cas	533-31-3
ʻAna	≥99%
Palekana	nsoluble i loko o ka wai a i wai wai paha, hoʻoheheʻe maoli i ka waikawa Acetic, ethyl ester.
Papale ʻaʻa	138.12 g / mole
ʻO ka Melt Point	62 a 65 ° C (144 a 149 ° F; 335 a 338 K)
Ka Lā Molecular	C7H6O3
ʻO ka paila	21 a 127 ° C (250 a 261 ° F; 394 a 400 K) i ka 5
SMILES	mmHgO1c2ccc (O) cc2OC1

 

He aha ʻO Sesamol?

ʻO Sesamol kahi hui phenol kūlohelohe i loaʻa i ka aila sesame i hana ʻia a me nā ʻanoʻano sesame i hoʻomoʻa ʻia. ʻO Sesamol (CAS 533-31-3) manaʻo ʻia ka mea nui a me ka mana o ka sesame aila i hana i kāna hopena therapeutic.

Sesame (Sesamum symbum) he aila waiwai nui i ka ʻohana Pedaliaceae. Ua manaʻo ʻia ʻo ia kekahi o nā ʻaila kahiko loa i ʻike ʻia a hoʻohana ʻia e ke kanaka no ka mea ʻaʻole wale i kāna waiwaiʻai akā ʻo ka waiwai lāʻau hoʻi. ʻO nā ʻāpana nui o ka sesame e hāʻawi ana i ka waiwai therapeutic he lau a me ka aila hua.

Loaʻa ʻo ka sesamol 533-31-3 compound i nā helu kumuwaiwai ʻē aʻe o nā hui lignin o ka aila sesame, sesamin a me sesamolin. ʻO kēia hui hiki ke hoʻoheheʻe ʻia ka wai kahi i manaʻo ʻia he antioxidant ikaika.

 

Pehea e sesamol work?

Hana ʻo Sesamol i nā ʻano ʻokoʻa e hāʻawi i kāna keu pono therapeutic e like me neuroprotection, nā hopena antioxidant, anti-inflammatory, anti-tumor, anti-radiation a me nā hopena scavenging radical.

Ma lalo iho nei kekahi mau ʻano i kahi sesamol e hana ai e hoʻokō i nā hopena i ʻōlelo ʻia;

 

I. Kāohi i ka hōʻino ʻia o DNA e ka stress oxidative

Hiki iā Sesamol ke kāohi i ka hōʻino ʻana iā DNA e ka radiation-induced stress. ʻO ka radiation Ionizing ke kumu o ka hōʻino ʻana i ka DNA pūnaewele ma o ka hoʻoulu ʻana i nā aberrations chromosomal a me micronuclei i nā pūnaewele hoʻonui.

 

II. Hoʻoulu i ka hana o nā antioxidant nui

Hana ʻo Sesamol e ka hoʻoponopono hou ʻana i nā hana o nā mea nui antioxidant enzyme e like me catalase (CAT), superoxide dismutase (SOD), a me glutathione peroxidase (GPx), i ukali ʻia me nā pae hoʻonui o ka glutathione hoʻemi (GSH). Paʻa kēia mau ʻelima i nā kuleana koʻikoʻi i ka pale ʻana i ka hōʻino ʻana o ke kelepona e nā radical.

 

III. Hoʻokiʻoki i nā protein pro-apoptotic a laila hoʻonui i ka hiki ke ola o ke kelepona

ʻO nā proteins Pro-apoptotic he mau protein e hāpai i ka make o ka cell. Pākuʻi ʻia lākou i nā p53, caspase-3, PARP, a me nā ʻenema ʻino. Pili kēia mau ʻenima i ka make o ke kolamu i hoʻolālā ʻia no laila e hoʻoliʻiliʻi i ka hiki ke ola o ke kelepona.

Ua hōʻike ʻia ʻo Sesamol e hoʻolaulaha i ke ola o ke kelepona ma o ka pāpā ʻana i ka hana o nā pro-apoptotic enzymes.

 

IV. Ka pāpā ʻana o ka lipid peroxidation

ʻO ka lipid peroxidation kahi ʻano o ka lipid degradation e kū nei ma muli o ka hoʻowali ʻana. ʻO kēia ka hopena i ke hoʻokumu ʻana i nā aldehydes reactive, e like me malondialdehyde (MDA) a me 4-hydroxynonenal (HNE) e hōʻino i ka cell. Ua hōʻike ʻia ʻo Sesamol e pale i ka lipid peroxidation a laila hāʻawi i ka pale i nā hunaola.

 

V. Pākaʻi i ka hanauna o nā radical manuahi me nā radical hydroxyl

ʻO nā radical manuahi nā hoʻohui paʻa ʻole e pili ana i nā maʻi a me nā ʻelemakule. ʻO nā radical Hydroxyl nā oxidant mana loa e kumu i ka maʻi.

Hoʻemi ka Sesamol i ka hanauna o nā radical manuahi me hydroxyl, α, α-diphenyl-β-picrylhydrazyl (DPPH), a me ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) kolohe.

 

VI. Hoʻonui i ka hana scavenging radical

Ma waho o ka pāpā ʻana i ka hanauna o nā radical manuahi, hiki i ka sesamol ke hoʻopau i nā radical manuahi e like me hydroxyl, lipid peroxyl a me nā radical tryptophanyl.

 

VII. Kaohi ʻana i nā hunaola ʻula

Ua kāpae ʻo Sesamol i nā ala hōʻailona e pili ana i ka hana ʻana i nā laha reactive no laila e hoʻoliʻiliʻi i ka pane ʻana o ka mumū.

 

VIII. Hoʻoemi i nā cytokine inflammatory (TNFα, IL-1β, a me IL-6)

ʻO Nitric oxide, i hana ʻia e iNOS, alakaʻi i ka mumū o ka mumū ma ka hoʻoulu ʻana i nā cytokine inflammatory, e like me TNFα, a me ka hoʻomaikaʻi ʻana i ka pane ʻōpala. Hiki iā Sesamol ke kāohi i ka hoʻokuʻu ʻana o TNFα a me IL-1β.

 

IX. Ka hopu ʻana i ka ulu ʻana o ka pūnaewele i nā pae like ʻole

Ua hōʻike ʻia ʻo Sesamol e hoʻowalewale i ka hopu ʻana o ka cell i nā ʻano ulu ulu like ʻole me ka pae S a me ka pae G0 / G1. Kōkua ʻo Sesamol anti cancer cancer i kahi waiwai, no ka laʻana, hōʻemi i ka ulu ʻana o ka maʻi ʻaʻai.

 

X. ʻO ka hoʻoulu ʻana i ke ala caspase

ʻO nā caspases nā enzyme e pili ana i ka make cell i hoʻolālā ʻia. Ua hōʻike ʻia ʻo Sesamol e hoʻohana i kēia mau ala no laila a hiki i ka make ʻana o ka cell cancer.

 

XI. Hoʻokomo i nā apoptosis ma o nā ala intrinsic a me extrinsic

ʻO Apoptosis kahi hana physiological kahi e make ai ka cell hoʻonohonoho. He hana nui ia e kōkua ai i ke kino e hoʻopau i nā hunaola make.

Hoʻokomo ʻo Sesamol i ka apoptosis ma nā ʻano ʻokoʻa ʻelua, ke ʻano intrinsic a me extrinsic.

 

XII. ʻO ka autophagy mitochondrial Hinders

ʻO ka autophagy Mitochondrial kahi ʻano degradation e kōkua i ka hoʻopau ʻana i ka mitochondria hemahema.

Ke pāpā ka sesamol i kēia kaʻina hana, a laila hoʻokomo ʻia ka apoptosis.

 

13. Hoʻoemi i nā pae nitrite a me neutrophil

Pāʻani nā Nitrites a me nā neutrophil i ka pane hoʻoweliweli. Pili lākou i ka hoʻokuʻu ʻia ʻana o ka nitric oxide nāna e hoʻopili i ka pane o ka hoʻohaunaele ma o ka hoʻoulu ʻana a i ʻole ke kāohi ʻana i ka mumū.

Pāʻani ʻo Sesamol ma ke ʻano he agena anti-inflammatory ma o ka hōʻemi ʻana i nā pae o nā nitrites a me nā neutrophil.

 

He aha sesamol i hoʻohana ʻia no?

Hoʻohana ʻia ʻo Sesamol no nā pono olakino like ʻole me;

 

i Piʻi koko kiʻekiʻe.

Hoʻohana ʻia ka ʻaila Sesame me kekahi mau lāʻau kaomi koko e like me ka lāʻau i hōʻoia ʻia e hoʻohaʻahaʻa i ke kaomi koko.

ʻO ka noiʻi ākea e pili ana i ka aila sesame e hōʻike nei i ka sesamol a me ka sesamin (lignans i loaʻa i ka ʻaila sesame) he kuleana nui i ka hoʻoponopono ʻana i ke kahe o ke koko. Lawe i ka aila sesame, ʻoi aku ka kuke ʻana me ia, no ʻekolu mau pule e hoʻohaʻahaʻa i ke kahe o ke koko no ka poʻe me ke kiʻekiʻe i ka maʻamau.

I loko o ka noiʻi, ua hoʻokau nā kauka olakino i kahi hui o nā mea maʻi hypertensive i nā lāʻau lapaʻau (Procardia, Nefedica a me Adelta) no kekahi mau lā 21. ʻOiai ua emi iki ka hoʻēmi ʻia o kā lākou kaomi koko, ʻaʻole ia i maʻamau. Ua hoʻohana ʻia ka ʻaila Sesame ma ke ʻano he pani no nā lāʻau, a ua hoʻāʻo ka poʻe maʻi ma hope o ka manawa like. ʻO ka hopena i hāʻule ke kahe o ke koko i ka maʻamau.

Ua hoʻopaʻapaʻa nā kauka ua hāʻawi nui ʻia ka hopena e nā nui o ka sesamol a me ka sesamin i loko o ka ʻaila sesame i kuke ʻia. Inā pēlā i ʻike ʻia e komo ana ka aila sesame i ka papaʻai no ka poʻe me ke koko kiʻekiʻe hiki ke ʻoi aku ka maikaʻi ma mua o ke kau ʻana iā lākou i ka lāʻau.

Ua hōʻike ʻia kēia mau hopena i ka American Heart Association i ka manawa o ka hui makahiki o ka Inter-American Society of Hypertension na Professor Devarajan Sankar o ke Kulanui ʻo Annamalai, India.

 

ii. Pākuʻi i ka ʻōpū.

ʻO ka noiʻi e pili ana i nā hopena o ka sesamol ma ke kahe o ka ʻōpū e hōʻike ana he ʻoi aku ka maikaʻi ma mua o ka aspirin. Ma kahi noiʻi e pili ana i ka ulcerative colitis, kahi IBD (maʻi ʻōpū o ke kīpē), kahi e hōʻino ai i nā aʻa mucosal ma o ka disregulate ʻana i ka ʻōnaehana hoʻoweliweli. I loko o kahi noiʻi e pili ana i nāʻiole, ua loaʻa ka sesamol e hōʻemi ai i nā hana o ka hoʻowali ʻana i nā ʻōhua.

ʻOiai ʻike ʻia ka aspirin e hoʻomake pono i nā maʻi mumū ke ʻai ʻia, hiki i ka ulu ʻana o ka maʻi ulcer i ka hoʻohana wā lōʻihi. Hoʻokumu ʻo Aspirin i nā ʻeha gastroduedonal e ke kau ʻana i nā pūnaewele.

Hōʻike ka noiʻi hou aʻe i ka intubation nasogastric o sesamol i nā mea maʻi e loaʻa ana i ka hanu liʻiliʻi o ka ʻōpū me ka mālama maʻamau e hoʻohaʻahaʻa i nā manawa o ke ʻoki ʻana.

 

iii. Maʻi maʻi puʻuwai.

ʻO nā kumu kūpilikiʻi i hāʻawi ʻia e nā maʻi maʻi maʻi maʻi he hapa nui i ka make a me ka maʻi o ka honua. Hiki iā lākou ke alakaʻi i ke koʻikoʻi oxidative a inā e hoʻomāhuahua ʻole ʻia i ka hoʻonui ʻana i ka hana pf reactive oxygen species, e like me ka ʻōnaehana antioksant defort.

Hoʻohana ʻo Sesamol i kāna mau pono anti-oxidative e kāohi i nā maʻi atherosclectoric cardiovascular e pili ana i nā kumu e like me hypercholesterolemia, hypertriglyceridemia, kiʻekiʻe kiʻekiʻe o ka lipoprotein kolesterol haʻahaʻa a me ka lipoprotein haʻahaʻa kiʻekiʻe.

Ua hoʻopau hou ʻia nā noiʻi hou ʻana he sesamol ka membrane e hoʻokūpaʻa ana a me nā hopena hoʻohaʻahaʻa lipid. Eia kekahi, hāʻawi ia i ka pale i ka myocardium e kūʻē iā DOX-i hoʻokomo ʻia i ka cardiomyopathy.

 

IV. Ulu keiki.

Hoʻohana ʻia ʻo Sesamol i ka laulā o ke ʻano hoʻomohala keiki. I nā ʻano haʻawina like ʻole, ua hoʻohana ʻia ka sesamol no ka hoʻēmi ʻana i ka ADHD i nā keiki i hana hewa ʻole i ka noʻonoʻo inā i hoʻohana ʻia i nā mea liʻiliʻi. ʻO ka hemahema DHA maʻa mau i nā keiki me ADHD.

Hōʻike nā noiʻi he ʻumi ma mua i nā pōmaikaʻi maikaʻi i nā ʻōuli ADHA me ka heluhelu ʻana i ka huaʻōlelo, ka impulsivity, ke aʻo ʻana i ka ʻike, ka hoʻomanaʻo hana ʻana, a me ka hyperactivity.

Ua lomilomi nā kamaliʻi i ka aila sesame no ʻehā mau pule i hoʻopaʻa i ka ulu a me ka hoʻoikaika kino.

 

v. ʻO ka maʻi maʻi.

Hana maikaʻi ʻo Sesamol ma ke ʻano he mea kōkua i ka lāʻau diabetes e hoʻohaʻahaʻa i ke kiʻekiʻe o ke kō i ke kō. Lawe i nā mea hoʻopihapiha sesamol a i ʻole ka loli ʻana i kaʻai aila sesame ʻoiai ma nā lāʻau diabetes e hāʻawi i kahi hua maikaʻi no ka hana.

I kekahi mau noiʻi ʻana, ʻo ka hapanui e pili ana i ka poʻe maʻi o ka maʻi ʻaʻai ʻano 2, ua hōʻike ʻia ka sesamol i nā hopena maikaʻi loa. ʻO kekahi o nā noiʻi ʻana e pili ana i ʻekolu mau pūʻulu, e loaʻa ana i kēlā me kēia maʻi i ka maʻi diabetes type 2. Hoʻokomo ʻia kahi hui i ka sesamol hoʻokahi, ʻo kekahi i nā lāʻau lapaʻau lāʻau o ka glibenclamide (Glyburide), a ʻo ka hope i nā sesamol a me Glyburide no kahi manawa ma kahi o 7 mau pule.

Ua hōʻike ʻia ʻo Sesamol i ka hopena synergetic me ka glyburide, ʻoiai ua hoʻoliʻiliʻi ka hoʻolauna hui i nā hemoglobin A1c a me nā kō i loaʻa i ke kō, a ʻoi aku ka maikaʻi ma mua o kekahi o nā hoʻoponopono hoʻokahi.

Hyperlipidemia. Hōʻike nā kānaka noiʻi ua hoʻohana ʻia ka sesamol no ke kuni ʻana i ka kolesterol a me nā lipid ʻē aʻe i ke koko i nā hopena maikaʻi. I kahi hōʻike hoʻohālikelike, ua hoʻāʻo ʻia ka maikaʻi o sesamol no ka hyperlipidemia i hoʻokomo ʻia i ka momona momona, hyperlipidemia maʻi, hypercholesterolemia, a me hyperlipidemia koʻikoʻi.

Hoʻoemi i nā pae triacylglycerol e like me ka hopena i hōʻike ʻia e hoʻemi nui ka sesamol i ka lawe ʻana triacylglycerol. Hoʻohana ʻia ʻo Sesamol e hoʻohuli i nā kiʻekiʻe kolesterol kiʻekiʻe.

Hōʻike nā noiʻi e hoʻonui ka sesamol supplement i ka excretion o ka cholesterol a me ka hoʻēmi ʻana i kāna omo.

 

VI. ʻO ka maʻi Metabolic a me ka momona.

Hōʻike ʻia ʻo Sesamol i loko o nā ʻano meaola like ʻole e like me ka hiki ke hoʻi i ka momona a me nā maʻi metabolic. Hōʻike ʻia e kāohi paha i nā hopena anti-obesity.

Ua mālama ʻia ka noiʻi e hōʻike i ka maikaʻi o ka sesamol ma luna o ka momona, ua ʻike ʻia ua hiki ke hoʻoponopono i ka metabolism lipid hepatic. Ma hope mai ua hoʻomaikaʻi i ke kūpaʻa ʻana o ka insulin a hoʻonui i ka pohō kaumaha. ʻO ka nui a me nā maʻi metabolic pili e pili nui i ka lipid hōʻuluʻulu i loko o ke kino. ʻO ka hōʻemi hōʻiliʻili ʻia ʻo ia hoʻi ka hoʻohuli i ke ʻano momona.

Hoʻohana Sesamol hoʻonui i ka lipolysis, ka hoʻowai ʻana o ka waikawa momona a me ka helu hoʻemi o ka lipogenesis hepatic, nā mea nui i ka hoʻohaʻahaʻa ʻana o ka lipid. ʻO kēia mau hana (ʻo ia hoʻi ka lawe ʻana o lipid, synthes a me catabolism) i waena o nā mea he nui i hana ʻia i ke ake.

Ua hōʻike ka poʻe e hoʻohana ana i ka sesamol i nā maikaʻi hepatic maikaʻi a me ka lipum serum, a me ka noʻonoʻo insulin hoʻonui ʻia.

 

vii. Rheumatoid arthritis, Osteoarthritis, a me ka osteoporosis.

ʻOiai ʻo ka rheumatoid arthritis, kahi maʻi ʻeha a mau loa autoimmune, he mau ʻano lāʻau kemika, ʻo kā lākou hoʻohana wā lōʻihi he hepatotoxic. Hiki iā Sesamol ke lilo i lāʻau lapaʻau kūlohelohe. ʻO nā noiʻi e noiʻi ana i ka mea like, ua hōʻike ʻoi aku ka maikaʻi o ka sesamol i nā anti-arthritic a me nā anti-inflammatory effects i hoʻonui pono i nā hopena o ka rheumatoid arthritis.

ʻO Osteoarthritis kahi mea kōkua nui i ka ʻeha pū, i manaʻo ʻia e hoʻopili ma kahi o 15% o ka heluna o ka honua. Eia naʻe, ʻo ke koʻikoʻi oxidative kahi hapa nui i ka hana ʻole o nā iwi skeletal. Ua hōʻike ʻia ka noiʻi ʻana i nā hopena o sesamol ma osteoarthritis-i ʻeha pū ʻia e pili ana i ka lawe ʻana i kahi waihona sesamol no hoʻokahi pule i hiki ke hoʻohaʻahaʻa i kaʻeha. Hāʻawi ʻia kēia i ka waiwai anti-oxidative stress o sesamol.

Ua hoʻoholo nā ʻepekema i kahi hana like i ka postmenopausal osteoporosis ma lalo o ka hele ʻana e hana i ka ovariectomy, kahi e lilo ai ka nalo holomua i ka kaupaona iwi a me ka ikaika. No laila ua ʻike ʻia ka pili nui ʻana o ka iwi i ka estrogen. Hōʻike ʻia ʻo Sesamol e hoʻopaʻa i nā estrogen receptor a hoʻoulu i nā genes pane pane i ka estrogen. Paipai nā hopena maikaʻi i ka ikaika o ka iwi ma ka hana ʻana i nā protein matrix iwi.

 

viii. ʻO ka maʻi Alzheimer, ka pīhoihoi a me ka hahau.

ʻO ka maʻi Alzheimer kahi maʻi lolo holomua e pili ana i ka hoʻohaʻahaʻa ʻana o nā lolo. Hoʻopau pinepine ia i ke kūʻokoʻa noʻonoʻo o nā mea i hoʻopilikia ʻia. Ua ʻōlelo ʻia nā hopena neuroprotective o sesamol. Ua hoʻonohonoho ʻia kahi noiʻi e elucidate i ka hiki therapeutic o sesamol i ka epilepsy, kahi kūlana i pili nui ʻia i ka noʻonoʻo ʻole a me ke kaumaha oxidative. Ua hoʻopau ka noiʻi i ka sesamol i nā hopena ameliorative e kūʻē i ka hahau, ka hoʻohaʻahaʻa noʻonoʻo, ka hopu ʻana, a me ke koʻikoʻi oxidative. Hoʻohana maikaʻi ʻo Sesamol no ka lāʻau antiepileptic.

 

Nā pono Sesamol

[a]. ʻO Sesamol Anti-oxidant waiwai

Kūpono ke kaumaha oxidative ke loaʻa ke kaulike ʻole i nā hana radical manuahi a me nā antioxidant i loko o ke kino. Ke alakaʻi pinepine nei kēia i ka hōʻino ʻana o ka cell a me ke koʻikoʻi oxidative i manaʻo ʻia ma ke kumu o nā maʻi he nui.

ʻO ke koʻikoʻi oxidative kahi hana physiological kūlohelohe e alakaʻi i ka ʻelemakule.

ʻO nā Antioxidant ma ka ʻaoʻao ʻē aʻe he mau mea pale i ka hōʻino ʻana o nā hunaola ma muli o nā radical free. Kāhea pinepine ʻia lākou he poʻe scavenger radical free.

ʻO Sesamol ka mea ikaika a ikaika loa o ka antioxidant o ka sesame aila. Hana ia ma o nā ʻano hana like ʻole e lawe i nā hopena antioxidant. Hoʻopili kēia mau ʻano hana i ka hoʻoponopono ʻana i nā hana antioxidant nui, ka pale ʻana o DNA mai ka hōʻino ʻana o ka radiation, scavenging free radicals, inhibiting lipid peroxidation, a me ka pale ʻana mai nā radiation ultraviolet.

Ke aʻo ʻana e loiloi ana i ka hana radioprotective o sesamol e kūʻē i ka irradiation gamma i DNA. Hoʻokomo ʻia ka pōʻino DNA ma o ka hoʻolauna ʻana i hoʻokahi a i ʻole pālua i haʻihaʻi ʻia i loko o ka hanauna o nā ʻano oxygen olaola.

Ua loaʻa ʻo Sesamol e kāohi i nā haki DNA kū hoʻokahi. Ua hoʻemi ia i nā pae o nā radical manuahi e kikoʻī ana i ka hydroxyl, DPPH, a me nā radical ABTS, i hoʻopili ʻia a pau i nā haʻihaʻi hoʻokahi a i ʻole pālua ʻia i hoʻolauna ʻia.

 

[b]. ʻO Sesamol Pāʻani-inflammatory maika

ʻO ka hoʻāla kahi hana physiological kūlohelohe a ke kino e hoʻohana ai e hakakā i nā ʻelele haole e like me bacteria, fungi, a i ʻole ʻeha. Eia nō naʻe, hoʻopōʻino ke kuni hoʻomau i ke kino ke alakaʻi ia i nā ʻano maʻi like ʻole.

Kōkua nā mea anti-inflammatory i ka pale ʻana i ke kino mai ka hōʻino ʻana e ka hakakā ʻana i ka wela. Hana ʻo Sesamol ma o nā ala like ʻole e hāʻawi i nā hopena anti-inflammatory. ʻO kēia ʻano o ka hana pū me ka pāpā ʻana i nā hunaola hoʻohaʻahaʻa, hoʻēmi ʻana i nā hana nitrites a me ke kāohi ʻana i ka hana a me nā ala uila.

I loko o kahi noiʻi o nāʻiole me ka lipopolysaccharide LPS i hōʻeha ʻia i ka maʻi, loaʻa ka sesamol e kāohi i nā cytokine anti-inflammatory a me ka mea i keʻakeʻa i ka hana ʻana o nitric oxide a me prostaglandin E2 (PGE2) Ua loaʻa pū kekahi ʻo Sesamol e hoʻoponopono hou i ka adenosine monophosphate-activated protein kinase (AMPK) hoʻouluulu. Kōkua kēia i ke kāohi i ka palaho a hoʻoliʻiliʻi hoʻi i ka hōʻino ʻana o ka cell.

[c]. Maʻi ʻaʻai Sesamol waiwai

ʻO Sesamol loaʻa iā ia nā waiwai e kōkua i ke kaua ʻana i nā hunaola maʻi pū me ka hana anti-proliferative ma o nā ʻano hana like ʻole e like me ke kaohi ʻana i ka hiki ʻana o ka membrane, ka hopu ʻana i ka ulu ʻana o ka pūnaewele i nā pae like ʻole a me ka hoʻoulu ʻana i ka apoptosis.

I kahi noiʻi e pili ana i ka laina cell cancer cancer ʻo DLD-1 kanaka, ua hoʻohana ʻia ʻo sesamol i ka mahele lāʻau o 12.5-100 μM. Ua ʻike ʻia ua hoʻemi ʻia ka hana transcriptional COX-2 e 50%.

I kahi noiʻi ʻē aʻe, ua hoʻohana ʻia ka sesamol ma kahi mahele kiʻekiʻe o 0.5-10 mM e hoʻoulu ai i ka apoptosis ma HCT116 e ka hoʻonui ʻana i ka oxygen reactive intracellular (O2 • -) i kahi ʻano hilinaʻi lāʻau. Ua alakaʻi kēia i ka hoʻoulu ʻana o ke ala hōʻailona JNK e paipai ana i ka pōʻino mitochondrial. ʻO kēia ka hopena i ka hoʻokuʻu ʻana o cytochrome c i ka hopena e hoʻoulu i ka caspase a laila e hoʻoulu i ka apoptosis.

 

[d]. Seasomol Anti-mutagenic waiwai

Pili ka Mutagenicity i ka hiki o ka agena (mutagen) e hoʻokumu i nā hoʻololi. ʻO ka hoʻololi ʻana i hoʻololi i nā mea kūlohelohe hiki ke alakaʻi i ka hōʻino ʻana o ka cell a manaʻo ʻia he kumu no kekahi mau maʻi e like me ka maʻi ʻaʻai.

Ua hōʻike ʻia ʻo Sesamol e loaʻa nā waiwai anti-mutagenic ikaika. Hāʻawi ʻia kāna mau pono anti-mutagenic i ka hana antioxidant a ʻoi aku ka hiki ke hōʻoki i nā radical free.

I loko o kahi noiʻi, ua hoʻokomo ʻia ka mutagenicity e ka hanauna o nā radical oxygen e tert-butylhydroperoxide (t-BOOH) a i ʻole hydrogen peroxide (H2O2). Ua loaʻa ʻo Sesamol e hana i nā hopena anti-mutagenic ikaika i ka Ames tester ʻoihana TA100 a me TA102. ʻO ka kānana TA102 ʻike ʻia e maʻalahi loa i nā ʻano oxygen o ka reactive. Ua hōʻike pū ʻia ʻo Sesamol e kāpae i ka mutagenicity o sodium azide (Na-azide) i ka TA100 tester strain.

 

[e]. ʻO Sesamol hoomalu ana mai ka pāhawewe

ʻO ke kukuna e pili ana i ka ikehu e holo i ke ʻano o nā nalu a i ʻole nā ​​ʻāpana. Hiki ke hana pinepine i ka uila i loko o kā mākou kaiapuni. Eia nō naʻe, hiki i ka ionizing radiation ke hōʻeha inā waiho ʻole ʻia kaohi. Hiki ke hōʻike pōkole i ka radiation i nā maʻi koʻikoʻi e like me ka radiation radiation a me ka lā.

ʻO ka hoʻonui ākea ʻana i ka pāhawewe e hana i nā maʻi ʻoi aku ka nui e like me ka maʻi ʻaʻai a me ka maʻi maʻi maʻi.

I ke aʻo ʻana i nā ʻiole me ka pōʻino DNA i hoʻokomo ʻia e ka pāhawewe, ua loiloi ʻia ka sesamol no kāna hana pale i ka pāhawewe. ʻO ka mālama ʻia ʻana o nāʻiole me sesamol ka hopena o ka pale ʻana i ka hōʻino ʻia o DNA i hoʻoiho ʻia e ka radiation.

 

[f]. Hoʻolaha

Ua hōʻike ʻia ʻo Sesamol e hāʻawi i ka pale i ka puʻuwai mai nā ʻeha.

I loko o kahi noiʻi e loiloi ai i ka hiki ke pale o sesamol e kūʻē i ka hōʻeha myocardial, lawelawe ʻia ka sesamol pretreatment ma (50 mg / kg) no 7 mau lā ma mua o ke kaʻina ʻoki.

Ua ʻike kēia noiʻi ua hoʻemi nui ka sesamol i ka nui o ka infarct, ua hele i nā māka cardiac, ua kāohi ʻia i ka lipid peroxidation, neutrophil infiltration a me ka hāpai ʻana i ka pae antioxidants. , a hoʻonui pū i ka hana o ka anti-apoptotic Bcl-3 protein.

 

[g]. ʻO Sesamol Manuahi nā radicals scavenging

ʻO nā radical manuahi he ʻātoma paʻa ʻole e kiʻi maʻalahi i nā electrons mai nā ʻētoma ʻē aʻe. He pōmaikaʻi lāua ʻelua a ʻona hoʻi i ka hilinaʻi ʻana i kā lāua kūpaʻa. Ma nā pae haʻahaʻa e pāʻani ana nā radical manuahi i ka pane ʻōnaehana, eia naʻe, ke kiʻekiʻe loa ko lākou koʻikoʻi a lilo lākou i mea weliweli. Hoʻolālā nā radical manuahi i ke koʻikoʻi oxidative e hōʻino ai i nā hunaola a hiki ke kumu i nā maʻi maʻamau a degenerative e like me ka maʻi ʻaʻai, nā maʻi puʻuwai, a me nā maʻi o ka maʻi, cataract, a me nā maʻi neurodegenerative.

Kākoʻo ko mākou kino i nā hopena o ke kaumaha oxidative ma o ka hana ʻana i nā antioxidant akā ʻaʻole lawa paha lākou a koi i ka hoʻopihapiha ma o nā meaʻai a i ʻole nā ​​mea hoʻopili.

Loaʻa iā Sesamol ka hiki ke kāohi i ke hoʻokumu ʻana o nā radical manuahi a me ka scavenge i nā radical manuahi.

I loko o kahi noiʻi ʻana e pili ana i ka ʻili kanaka dermal fibroblast mākua mākua (HDFa) i hōʻike ʻia i UVB, ua loiloi ʻia ka sesamol pretreatment e pili ana i ka cytotoxicity, intracellular reactive oxygen species (ROS), lipid peroxidation, antioxidant status, and oxidative DNA harm. Ua loaʻa ʻo Sesamol e hoʻoliʻiliʻi nui i ka lipid peroxidation, cytotoxicity, intracellular ROS, a me nā oxidative DNA i hōʻino ʻia i nā hunaola dermal o ka ʻili kanaka. Ua hāʻawi ʻia kēia i ka hiki ke kōkua o sesamol supplement e scavenge ROS.

Ua hōʻike ka mea like noiʻi i ka hoʻonui ʻia o ka hana enzymatic a me ka non-enzymatic e kōkua ai i ka hana antioxidant ʻoi aku ka maikaʻi.

 

[h]. Hoʻohaʻahaʻa i ke kōpaʻa koko

ʻO ke kōpaʻa o ke kō he momona-like, waxy waiwai i kou kino. Pono ʻia i ke kino e kūkulu i nā hunaola olakino akā i nā helu kūpono. Lawe ʻia ʻo Cholesterol ma ʻelua ʻano lipoproteins, haʻahaʻa haʻahaʻa, a me nā kiʻekiʻe kiʻekiʻe. Lawe ʻia i ʻelua ʻano kolesterol, ʻo ka lipoprotein haʻahaʻa (LDL) kolesterol, a me ka lipoprotein (HDL) kolesterol kiʻekiʻe.

Kāhea ʻia ka LDL ma ke ʻano he kolesterol maikaʻi mai ka wā kiʻekiʻe o ka LDL hoʻonui i kou makaʻu i ka maʻi o ke aʻa a me nā maʻi ʻē aʻe.

Hiki i ka Sesamol ke hoʻēmi i ka pae o ke kōkōlani a me ka pae o ka triacylglycerol i ke kino.

I kahi hōʻike hoʻomanawanui momona, sesamol (100 a me 200 mg / kg) ua loaʻa i ka nui (P <0.05) hoʻemi i ka lawe ʻana o triacylglycerol no laila ke hoʻohaʻahaʻa nei i ka pae o ka triacylglycerol i ke kino. ʻO Triacylglycerol ka mea nui o ka momona i mālama ʻia i loko o kaʻiʻo adipose.

I ke aʻo ʻana o nā ʻiole Swiss albino me ka hyperlipidemia i hoʻokomo ʻia, ua hōʻike ʻia ka hoʻonui ʻana o ka sesamol ma 50 a me 100 mg / kg e hoʻoliʻiliʻi nui i nā kiʻekiʻe o nā kolesterol a me triacylglycerol.

ʻO ka hana o ka sesamol e hōʻemi ana i ka pae kolesterol a me ka triacylglycerol e pili ana i ka hiki ke hōʻemi i ka lawe ʻana a me ka hoʻonui ʻana i ka excretion o ka kolesterol.

 

[i]. Loaʻa ka Sesamol i ka ʻili

ʻO ka ʻili kanaka kahi ʻāpana hoʻohui o ka ʻōnaehana integumentary nona ka hana mua e hāʻawi i ka pale i nā kino o ke kino.

Hoʻomaikaʻi ʻo Sesamol i ka ʻili ma nā ʻano like ʻole ma muli o kāna ʻano ikaika e like me ka antioxidant, a me ka hana anti-inflammatory. Hoʻomaikaʻi ʻo Sesamol i ka ʻili e

 

· Ka pale ʻana i ka ʻili mai nā kukuna ultraviolet (UV)

ʻO ke kū lōʻihi i ka lā ke alakaʻi i kahi hanauna kiʻekiʻe o ka oxygen reactive species (ROS), i kumu e hōʻino i ka ʻili e like me ka collagen degradation i ka dermis a me hyperplasia o ka epidermis.

Hiki iā Sesamol ke ʻokiʻoki i nā radical manuahi e kū ana ma muli o ka lōʻihi o ka puka ʻana o ka lā e pale ai i ka ʻili mai ka hōʻino ʻia o ka radiation radiation. Hāʻawi ia i kahi pale pale e kōkua ai i ka pale ʻana i ka ʻili mai hōʻino ʻia e nā kukuna UV.

Hōʻike nā noiʻi e hiki i ka sesamol ke hōʻemi i ka cytotoxicity i hoʻokomo ʻia e UV-irradiation. Hōʻike pū ʻia nō hoʻi e kāohi i ka biosynthesis melanin ma o ka hoʻohaʻahaʻa ʻana i ka ʻōlelo o tyrosinase, MITF, TRP-1, TRP-2, a me MC1R i nā hunaola melan-a.

Ua loaʻa kahi noiʻi ʻē aʻe hiki i ka sesamol ke keakea i ka synthes melanin ma o ka hoʻohuli ʻana i ka cAMP / protein kinase A (cAMP / PKA), protein kinase B (AKT) / glycogen synthase kinase 3 beta (GSK3β) / CREB, TRP-1, a me MITF i B16F10 nā pūnaewele

 

· Kōkua e mālama i ka ʻili huali

ʻIke ʻia ʻo Sesamol kahi antioxidant ikaika. Komo ia i loko o ka ʻili a hānai i ka ʻili. Kōkua kēia i ka loaʻa ʻana o ka ʻili uila.

 

· Hoʻopau i ka huehue

ʻO ka huehue kahi ʻano kahi e paʻa ai nā pores ʻili e ka aila, ka lepo, a me kekahi mau microorganism weliweli.

ʻO Sesamol Loaʻa iā ʻoe nā waiwai antibacterial e hiki ai iā ia ke kāpae i nā microorganism no laila loaʻa iā ʻoe ka ʻili me ka huehue.

 

· Hāʻawi i nā hopena anti-ʻelemakule

ʻO ka ʻelemakule kahi hana maʻamau a hoʻomau o ke ola. Eia nō naʻe hiki i ka ʻelemakule ʻōpio ke kū ma muli o kekahi mau kumu e like me ke kū lōʻihi i nā kukuna UV, ka hoʻohaʻahaʻa oxidative i waena o nā poʻe ʻē aʻe.

Hāʻawi ʻo Sesamol i kahi hana antioxidant ikaika e pale ai i ka ʻili a me ke kino mai ka hoʻoliʻiliʻi cellular a me ka hoʻomaikaʻi ʻana i ka hoʻohou ʻana o ka ʻili.

Ua hōʻike pū ʻia ʻo Sesamol e pale i ka hanana ʻana o nā laina, nā pores, a me nā wrinkle.

 

[j]. Nā pono Sesamol no ka lauoho

ʻO ka palapala kumuhana o ka aila sesame e hānai i ke poʻo, nā lauoho lauoho, a me nā ʻau. Hāpai kēia i ka ulu ʻana o ka lauoho olakino. Kōkua pū ia i ka hoʻōla ʻana i ke poʻo ʻino e nā kemika i ka wā o ka mālama ʻana i ka lauoho a me ka pena ʻana.

Hiki ke hina hina mua o ka lauoho ma muli o ka hoʻemi ʻia o ka hiki i ke kino ke hana i lawa melanin, a me nā kumu ʻē aʻe e like me ke koʻikoʻi oxidative, ka nohona hoʻololi genetic me kaʻai a me ka hoʻohana lāʻau.

Ua hōʻoia ka hiki ke mālama i ke kala o ka lauoho a hoʻopouli hoʻi i ka hina hina.

Ma waho aʻe, hiki i ka sesamol ke kōkua i ka hoʻopau ʻana i ka dandruff. Hiki i ka dandruff ma muli o ka ʻili maloʻo, nā hopena maʻi i nā huahana lauoho, a me ka ulu ʻana o ka fungus ma ka ʻili i waena o nā kumu ʻē aʻe. Kōkua ʻo Sesamol i ka hānai ʻana i ka ʻili a laila mālama i kahi poʻo olakino e pale ai i ka hanana o ka dandruff. Hoʻomaopopo pū ka hana antibacterial i ka maʻi manuahi me ka ʻole o nā microorganism e kumu ai ka dandruff.

 

ʻEkolu ʻano hana synthetic o sesamole

. Lawe ʻia mai ka aila Sesame

ʻO Sesamol ʻO ka synthesist mai ka aila Sesame ka maʻalahi o nā ʻano ʻekolu. Eia naʻe, pipiʻi loa ia. No laila ʻaʻole kūpono kēia hana no ka hana ʻoihana, keu hoʻi ma muli o ke kumukūʻai hana kiʻekiʻe.

 

. ʻO ke synthetic synthetic e hele mai ana mai ka piperamine

ʻOiai kūpono ia no ka hana nui no ka hana Sesamol, ʻo ke ala holoʻokoʻa no ka syntam sesamol mai ka piperamine e pili ana i ka hana liʻiliʻi ma ka wā e hana ʻia ana ke kaʻina hydrolysis a me ka hoʻoliʻiliʻi hydrolysis. Me kēia mau ʻano, hiki i ka hoʻālaʻa puaʻa ma ke ʻano he hoʻopili a me nā ʻaoʻao ʻaoʻao i ʻole e hiki ʻole ʻia.

 

. ʻO ke ala semi-synthetic e hoʻomaka ana mai jasmonaldehyde

ʻO ke ala Semi-synthetic mai ka jasmonaldehyde ka mea i hoʻohana nui ʻia ka sesame phenol synthesis synthehish e like me ka manaʻo o nā kumu waiwai. ʻO ke kaʻina e pili ai i ka maʻi hoʻoliihua a me ka hydrolysis a ma muli o kēlā, ke kūmole hōʻailona sesame he mea kiʻekiʻe a ʻoi ke kala maikaʻi.
Hoʻohana ke kaʻina hana i ka ʻenehana hoʻoiho oxidant a me ka ʻenehana hoʻoiho hou, e hiki ai i ka hoʻokaʻawale wikiwiki ʻana o ka huahana mai ka wahi hoʻoiho. Hoʻoemi kēia i ka hiki i ka hopena o ka hopena ke ʻano nui. ʻAʻole he mea kupanaha ʻo ka huahana hope loa (ke aniani e like me ke keʻokeʻo) ke kiʻekiʻe kiʻekiʻe e pili ana i ke kala a sesamol nuʻa.

 

Kahi e kūʻai i ka sesamol

Loaʻa ka pauka Sesamol ma ka pūnaewele mai nā ʻano like ʻole nā mea hana sesamol. ʻO ka hapa nui o nā mea hoʻohana o sesamol e kūʻai mai nā mea like ʻole paena, kekahi no nā mea kūʻai aku a kūʻai nui paha.

Hōʻoia i ke kūpono o kēlā me kēia mea hana sesamol e hoʻohana nei i nā kānāwai mokuʻāina i hōʻike ʻia ma mua o ke kūʻai ʻana.

 

E hoʻomaopopo '

1. ʻO Joo Yeon Kim, Dong Seong Choi a me Mun Yhung Jung "Hana Antiphoto-oxidative o Sesamol ma Methylene Blue- a me Chlorophyll-Sensatio Photo-oxidation o ka Aila" J. Agric. ʻO Chem Chem., 51 (11), 3460 -3465, 2003.
2. Kumar, Nitesh & Mudgal, Jayesh & Parihar, Vipan & Nayak, Pawan & Nampurath, Gopalan Kutty & Rao, Chamallamudi. (2013). Hoʻoemi ka mālama Sesamol i ka Plasma Cholesterol a me nā pae Triacylglycerol ma nā Keole Mole o ka Acute a me ka Hyperlipidemia Kākoʻo. Lipida. 48. 633-638. 10.1007 / s11745-013-3778-2.
3. Majdalawieh, AF, & Mansour, ZR (2019). ʻO Sesamol, kahi lignan nui i nā hua sesame (Sesamum indicum): ʻO nā waiwai anti-cancer a me nā hana e hana ai. European Journal of Pharmacology, 855, 75–89.DOI: 10.1016 / j.ejphar.2019.05.008.
4. Ohsawa, Toshiko. "ʻO Sesamol a me sesamol e like me nā antioxidants." ʻOihana ʻAi Mea Hou (1991), 33 (6), 1-5.
5. Sesamol Archive 2010-01-14 ma ka Wayback Machine ma Chemicalland21.com
6. Wynn, James P .; Kendrick, Andrew; Ratchie, Colin. "ʻO Sesamol ma ke ʻano he mea hōʻoki i ka ulu a me ka lipid metabolism i Mucor circinelloides ma o kāna hana ʻana i ka malic enzyme." Lipids (1997), 32 (6), 605-610.