Lorcaserin

He nui ka lako o ka mea maʻi o ka lorcaserin, a he ʻano mana hoʻokele piha.

Hōʻike 'ia 1-3 o 6 hualoaʻa

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He aha ʻo Lorcaserin?

ʻO Lorcaserin (Belviq) kahi mea anti-obesity. Inā ʻoe no ka lūlū ʻana i ke kaumaha o ke kino me ka ʻole o ka pīhoihoi e pili ana i nā hana luhi, eia ka mea āu e hoʻomaopopo ai ma mua o ke kūʻai ʻana i ka lāʻau serotonergic.
Ua hoʻomohala ʻia ʻo Lorcaserin hydrochloride e Arena Pharmaceuticals. I loko o nā makahiki, ua hoʻohana ʻia ia ma ke ʻano he lapaʻau lōʻihi no ka momona. Hoʻopau ka waihona i ka makemake ma ka hoʻonui ʻana i ka māʻona. Ma waho aʻe, ʻaʻole pono ka pono ʻo lorcaserin iā ʻoe e hāhai i kekahi papa ʻaina koʻikoʻi a i ʻole nā ​​hana hoʻoikaika kino.
Mai kona hoʻomaka ʻana, ua hoʻokau ʻia ka lāʻau lapaʻau i nā hoʻokolohua preclinical he nui a me nā noiʻi kanaka e ʻike i ka hopena a me ka hoʻomanawanui ʻana i ka mālama ʻana i ka momona. I ka 2012, ua ʻae ka FDA i ka lorcaserin (Belviq) no ka hoʻohana therapeutic akā ma lalo o nā ana koʻikoʻi. ʻO kahi laʻana, ua loaʻa wale ke kauka no nā mākua momona a momona o ka poʻe i loaʻa i nā maʻi pili i ke kaupaona e like me hypertension, diabetes, a me dislipidemia.
Aia kekahi mau inoa inoa lorcaserin kaulana, ʻo ia hoʻi, Belviq a me Belviq XR. ʻAneʻane like lāua ʻelua, ʻo ka loaʻa ʻana o ka lorcaserin hydrochloride i mea hana.
ʻOi aku ka liʻiliʻi o nā capsule Belviq, a hoʻokaʻawale ʻia ka laulā o ka mahele i ʻelua i kēlā me kēia lā. ʻOi aku ka nui o nā capsule Belviq XR. Kēia inoa lorcaserin inoa he ʻalani hoʻolōʻihi-hoʻokuʻu hoʻokuʻu ʻia e lawe hoʻokahi i ka lā.


ʻO Lorcaserin lāua ʻo Lorcaserin Intermediates

ʻO Racemic Chlorocaserin Hydrochloride

Kāhea ʻia kēia hui ʻo lorcaserin hydrochloride. Eia nō naʻe, kona inoa ʻepekema ʻo 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride (CAS: 1431697-94-7).
Loaʻa ka Racemic Chlorocaserin Hydrochloride kaola mai ka hoʻohuihui ʻana i ka dextrorotatory chlorocaserin hydrochloride a me ka lev-rotatory chlorocaserin hydrochloride. Hoʻohana ʻia ka waena waena lorcaserin i ke aʻo ʻana a me ka hoʻomākaukau ʻana i kahi lāʻau hoʻoliʻiliʻi kaumaha.

ʻO Dextrorotatory Chlorocaserin Hydrochloride

Hoʻomaopopo kemikala ʻia ka mea ma ke ʻano (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (CAS no: 846589-98-8). Eia nō naʻe, i nā ʻōlelo a ka poʻe, ʻo ia (R) lorcaserin hydrochloride.
ʻO kēia lorcaserin waena he mea maka aniani no ke aʻo ʻana i nā lāʻau lāʻau o nā lāʻau lapaʻau kaumaha. I nā hana preclinical me nāʻiole, hōʻike ka mea hoʻohui i nā hopena anorectic. Ma waho aʻe, hoʻemi ia i ka lawe ʻana o analgesics a me narcotics e like me ka caffeine, amphetamine, a me nā lāʻau e pili ana.

ʻO Casserole ʻōmaʻomaʻo lima ʻākau

ʻEpekema, ʻo kēia (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine me CAS no. 616202-92-7.
Loaʻa ka casserole ʻōmaʻomaʻo ʻākau no nā kumu anamanaʻo a me nā aʻo. ʻAno agonistic ka mea i nā mea loaʻa he 5-HT2C, no laila he mea pono i ka noiʻi ʻana i nā lāʻau suppressant-suppressant.

ʻO Dextrorotatory Chlorocaserin Hydrochloride Hemihydrate

ʻIke ʻia kēia hui ma ke ʻano he lorcaserin hydrochloride hemihydrate. ʻO kona ʻano ʻepekema (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride hemihydrate (CAS: 856681-05-5).
ʻO Dextrorotatory Chlorocaserin Hydrochloride kahi mea maka no ka hoʻopili ʻana i ka lorcaserin.

Pākuʻi Manuahi Chlorocaserin

ʻO 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine kona inoa kemika (CAS no: 616201-80-0).
He huahana lāʻau lapaʻau-papa ʻo Racemic Chlorocaserin Free Base no ka hoʻohana ʻana i ka noiʻi a me ka ʻepekema.

Kākoʻo ʻo Green Card Serin waena

ʻO kona inoa ʻepekema ʻo 1 - [[2- (4-Chlorophenyl) ethyl] amino] -2-chloropropane hydrochloride (CAS no: 953789-37-2). ʻO Green Card Serin kahi mea waena i ka hoʻomākaukau ʻana o kahi kōkuʻu lorcaserin.
Pono ʻoe e hoʻomaopopo i kēia mau waena waena lorcaserin no ka noiʻi wale nō. ʻAʻole kūpono nā mea hoʻohui no ka ʻai kanaka a holoholona paha.


Pehea e hana ai ʻo Lorcaserin?

Hoʻopaʻa ʻo Lorcaserin (Belviq) i ka Pūnaewele Nervous Central ma o ka launa ʻana me nā receptor hypothalamic kikoʻī. Hana ia ma ka hoʻoulu ʻana i ka serotonin 2C (5-HT2C) ma nā neurons pro-opiomelanocortin. ʻO kēia ʻāpana o ka lolo ka lima i ka makemake a me ka hana ʻana i ka maʻamau. ʻOiai aia kekahi mau subtypes ʻē aʻe e like me 5-HT2A a me 5-HT2B, loaʻa i kēia lāʻau ke aloha kiʻekiʻe loa no 5-HT2C.
Hoʻopau ka Lorcaserin weight loss supplement i nā mea loaʻa nā 5-HT2C, no laila, e hoʻonāukiuki i ka hōʻike o nā hormones alpha-MSH. Hana ʻo Alpha-MSH ma nā melanocortin-4-receptor, e hoʻouna i nā hōʻailona i ka lolo ua piha ʻoe.
ʻO ka waiwai agonistic o lorcaserin me ka receptor 5-HT2C e hoʻonui i ka māʻona, no laila, e hoʻēmi nei i ka lawe ʻana o ka meaʻai a me ka hōʻeleu ʻana i ka pohō. Wahi a kekahi kuhiakau ʻepekema, hoʻololi kēia lāʻau serotonergic i nā pae o ka leptin, kahi hormone e hoʻokani i ka lilo o ke kaumaha. ʻO ka pākuʻi o ka hoʻohana ʻana i kēia kumukanawai me he agena anti-obesity ʻaʻole ia e kipaku aku i ka maʻi puʻuwai valvular. ʻO ke kumu no ka liʻiliʻi o ka agonistic i nā mea loaʻa ʻo 5-HT2B.


Nā Pono a Lorcaserin a me nā ʻaoʻao ʻaoʻao

maika

ʻO ka lawe ʻana i ka lorcaserin hydrochloride e hoʻonui ai i ka manaʻo o ka māʻona. Kōkua ia i nā maʻi ʻai, e like me ka mea maʻamau i ka poʻe e noʻonoʻo i ka naʻau a me ka binge. Wahi a nā hoʻokolohua hoʻokolohua lorcaserin kūleʻa, hiki i kekahi ke lilo ma kahi o 5% o ko lākou kino kaumaha i 12 mau pule.
ʻOiai he laha ʻole, ʻo ka lilo ʻana ma lalo o 5% o kou kaupaona ʻoiai ma lorcaserin ʻo ia hoʻi ʻaʻole ʻoe e hoʻokō i kahi hopena kūpono me ka lapaʻau lōʻihi. I kēia manawa, paipai nā kānaka noiʻi e hōʻoki i ka lawelawe ʻana i ka waihona kōkua hoʻemi kaumaha.
Ke hoʻohana nei i kēia mea hana serotonergic i kahi kānalua ʻole e hoʻomaka i ke kaʻina hana momona. Eia nō naʻe, pono ʻoe e hoʻohui i kekahi mau hana kino ʻoiai e pili ana i ka papa haʻahaʻa haʻahaʻa. Ma waho aʻe, ka maikaʻi o ka lorcaserin i ka hoʻokele hoʻokele kaumaha i ka hoʻoponopono mau. Hoʻomaha ka hoʻopau ʻana i nā hana i ka hopena maikaʻi ʻole i nā hopena.
Ma waho o ka mālama ʻana i ke kaupaona, hana pū kekahi ʻo lorcaserin ma ka hoʻokau ʻana i ka overactivation o ka dopamine i ka pane ʻana i kekahi mau narcotics e like me ka caffeine, morphine, codeine, a i ʻole nā ​​amphetamines. ʻO nā hopena agonistic o ka waihona ma nā serotonin receptor e kūpono no ka mālama ʻana i nā maʻi psychotic.
Wahi a nā ʻepekema, hiki i ka lorcaserin ke hoʻopau i nā ʻōuli o schizophrenia ma muli o ka hoʻoliʻiliʻi o ka hoʻokuʻu ʻia ʻana o ka dopamine.

Nā Huaʻaoʻao
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Ma mua o ka hapalua o nā ʻōuli maikaʻi ʻole o ka lorcaserin HCl ma muli o ka nui o ka hana. Hiki iā ʻoe ke kāpae i nā hopena ʻaoʻao lorcaserin ma ka pili ʻana i ka mālama ʻana i ka lāʻau. ʻO kahi laʻana, ʻaʻole pono ʻoe e ʻoi aku i ka laulā o kēlā me kēia lā. I ka hihia o kahi overdose, e hōʻoia e ʻimi i nā ʻōlelo aʻoaʻo olakino. ʻO kekahi o nā hopena e nānā e pili pū me nā hallucination, nā loli o ka naʻau, ʻeha o ka ʻōpū, nā puʻuwai puʻuwai ʻole, a me ka hysteria.

Nā kūkākana:

Ma mua o ka lawelawe ʻana i ka pākuʻi ʻo lorcaserin HCl, pono ʻoe e noʻonoʻo i nā contraindications a me nā mālama ʻana i ka lāʻau.

  • Kūleʻa paha kekahi mea hoʻohana i nā mea lorcaserin
  • ʻAʻole pono nā wahine hāpai a me nā makuahine hānai e lawelawe i ka lorcaserin ma muli o ka hopena o ka pēpē
  • Pili pū paha ke kumukanawai me kekahi mau lāʻau i kuhikuhi ʻia a kuhikuhi ʻole ʻia a hoʻopilikia i kā lākou lāʻau lāʻau
  • Hoʻopiʻi ʻia ʻo Lorcaserin lāʻau hōʻemi kaumaha i nā mea maʻi i hiki i ka maʻi ʻaʻai a i ʻole nā ​​mea i loaʻa i ka maʻi

ʻO wai e hiki ke hoʻohana iā Lorcaserin?

He kōkua pono ʻo Lorcaserin i ka mālama ʻana i ka momona. Wahi a ke kānāwai FDA, kūpono kēia lāʻau serotonergic no ka poʻe kaumaha loa me ka BMI ma luna o 27kg / m2 a me nā mākua momona me kahi BMI ʻoi aku ma mua o 30kg / m2. Eia nō naʻe, kūpono wale ke kuhikuhi no nā mea maʻi e pili ana i ke kaupaona e like me ka dislipidemia, ke koko kiʻekiʻe, nā maʻi maʻi maʻi, a me nā hypertension.
Hiki i nā mea maʻi makua ke hana i kahi lorcaserin e kūʻai no ka mālama kaumaha kaumaha. Hoʻopili ma waena o nā hoʻokolohua hoʻokolohua me ka lāʻau i hōʻoia ma mua o nā kānaka ma mua o 18 mau makahiki. He aha hou aʻe, kona palekana a me kona pono i nā maʻi ma lalo o 18 mau makahiki ʻaʻole i hoʻokūpaʻa ʻia.
ʻOiai hiki i kekahi kanaka makua a paʻakikī paha ke hoʻohana i kahi kōkō o ka lorcaserin weight loss supplement, aia kekahi mau contra contications i kekahi mau hui. ʻO kahi laʻana, ʻaʻohe o ka nīnau nā wahine hāpai. Ma waho aʻe, ʻaʻole maopopo inā hele ka lāʻau i loko o ka waiū o ka waiū, no laila, kāpae ʻia nā makuahine lactating mai ka lawe ʻana iā ia.


He aha ka ʻokoʻa ma waena o Lorcaserin, Cetilistat, a me Orlistat?

Lorcaserin

ʻO Lorcaserin HCl kahi mea makemake nui-suppressant ʻoiai orlistat a me cetilistat kaohi i ka hydrolysis o triglycerides i loko o nā waikawa momona momona. Hoʻolālā ka mea hoʻonui i ka ʻāpana hypothalamic o ka lolo e hoʻoponopono ana i ka makemake a me ka piha. ʻO ka lawe ʻana i ka lorcaserin e hoʻomaka i ka māʻona a hōʻailona i ke kino ua piha ʻoe me ka nānā ʻole i ka liʻiliʻi āu i hoʻopau ai. No laila, keehi nei ka hoʻohaʻahaʻa kaumaha ma muli o ka hoʻemi ʻia o ka ʻai a me ka hōʻole o ka meaʻai.
Me ka lorcaserin, hiki i kahi mea hoʻomanawanui ke lilo aku ma mua o 5% o ko lākou kino kaumaha mua a me ka hōʻemi nui o ka pūhaka ma kahi o 3cm. Hōʻike ka lāʻau i nā loli nui ma mua o ka hoʻohana ʻana i ka listlist.
I ka 2012, ua ʻae ʻo lorcaserin hydrochloride i ka ʻae ʻia e FDA a lilo i lāʻau lapaʻau no ka momona a me nā comorbidities e pili ana i ke kaupaona. Eia naʻe, ua huki ka Federal Agency iā ia mai ka mākeke no ka hoʻonui ʻana o ka holomua o ka maʻi ʻaʻai i waena o nā mea hoʻohana.

Anailistat

E like me lorcaserin (Belviq), ʻo cetilistat kahi lāʻau anti-obesity. ʻO ka lawe ʻana i ka lāʻau lapaʻau e ālai i nā lipase pancreatic, nā kuleana no ka haki ʻana i nā triglycerides. A ʻo kahi hopena, ʻaʻole hydrolyze nā triglycerides i loko o nā waikawa momona manuahi no ka lawe maikaʻi ʻana i ke kino. No laila, e hoʻopau i ka momona
Hiki iā Cetilistat ke alakaʻi i kahi hōʻemi a 10% o ke kaumaha o ke kino a me ka hoʻoliʻiliʻi nui o ka pōʻai pūhaka.
ʻAʻole like me nā hopena ʻaoʻao lorcaserin, pili nui nā ʻōuli maikaʻi o cetilistat i ka digestion. ʻO kahi laʻana, e ʻike kekahi i nā noho ʻaila a hemo hoʻi, flatulence, neʻe mau o ka ʻōpū, a i ʻole incontinence fecal.
ʻAʻole i lanakila ʻo Cetilistat i ka ʻae ʻia o ka FDA no ka mea aia i kēia manawa i nā manawa mua o ka noiʻi kanaka. I kēia manawa, loaʻa nā hopena i ka hopena. ʻO ka hoʻohālikelike ma waena o nā helu helu olakino o cetilistat a me orlistat i hōʻoia i ka mea o mua e hoʻonui i ka hoʻemi kaumaha a ʻoi aku ka maikaʻi o ka hoʻomanawanui.
ʻO ka hua hoʻohui o cetilistat ʻaʻole ia e hana ma nā ʻōpū gastrointestinal ʻē aʻe a me ka ʻōnaehana nūhou. Wehewehe kēia mea i ke kumu o ka hapa iki o nā hopena maikaʻi ʻole.

Orlistat

Kōkua ʻo Lorcaserin a me orlistat i ka hoʻoliʻiliʻi kaumaha. Eia nō naʻe, ʻokoʻa ko lākou ʻano hana.
E like me cetilistat, Orlistat ke kāohi nei i ka gastric a me nā pancreatic lipases. Hoʻopilikia kēia mea pāpā i ka hydrolysis o triglycerides mai ka papaʻai a kekahi, no laila, hoʻopau ʻia nā momona momona āpau.
Wahi a nā hoʻokolohua hoʻokolohua i loaʻa, hiki i nā poʻe kānaka ke lilo i ka wikiwiki i ka hoʻohana ʻana i ka orlistat ma mua o nā mea ma kahi placebo. I ka hopena o ʻeono mau mahina, e ʻike ʻia nā loli i ke anapuni o ka pūhaka. Ma waho aʻe, ʻo ka lawe ʻana i ka lāʻau e hōʻemi i ke kahe o ke koko a me nā hanana o ka maʻi kō II.
ʻO Orlistat kahi koho lorcaserin kūpono i loaʻa ma ke ʻano he lāʻau lapaʻau no ka mālama ʻana i ka momona akā hiki nō hoʻi iā ʻoe ke kūʻai ma kahi kūʻai aku. ʻAʻole like ia me lorcaserin, aia nō kēia lāʻau i ka papa keʻokeʻo o ka FDA. E kūʻai aku ka hapa nui o nā mokuʻāina i ka waihona me ka ʻole o ka pono o ke kuhikuhi pono. Lawe, ma kahi laʻana, ma ka US, European Union, a me Australia, kūʻai maʻalahi i ka orlistat e like me ka uku ʻana no nā kāmaʻa sneakers ʻelua. ʻAʻohe o Orlistat hopena ma nā ʻenekini GIT ʻē aʻe a me ka ʻōnaehana hopohopo.

Ma kahi hāmole

ʻO Cetilistat a me orlistat nā ʻano koho lorcaserin no ka mālama ʻana i ka momona a me ka momona. Eia naʻe, e hoʻonui wale kā lākou mākaukau me nā hana o ke kino a me ka papa haʻahaʻa haʻahaʻa. ʻO Lorcaserin a me orlistat e hoʻēmi i ke kaupaona a me ka nui o ka pūhaka akā ʻo ka haʻalele ʻana i kā lākou mau hana e hoʻoliʻiliʻi ka mea hoʻohana i 35% o nā mea i nalowale.
I kēia manawa, ʻo ia wale nō ka mea hoʻopiha Cetilistat ʻaʻole i hana iā ia i ka US whitelist keʻokeʻo ʻoiai aia nō ia i nā hoʻokolohua hoʻokolohua. No orlistat, ʻo ka loaʻa ʻana e like ia me ke kūʻai ʻana i kāu paracetamol maʻamau. Kūlike ʻole, ke hana nei i kahi lorcaserin e kūʻai ai he mea hiki ʻole ia mai ka wā i hoʻopau ai ka US Federal Agency i kāna ʻae i ka hoʻomaka mua o 2020.
Hana maikaʻi nā lāʻau ʻekolu a akā he hopena ka cetilistat. Ma waho aʻe, heʻuʻuku kāna mau hopena a ua ʻae maikaʻi ʻia i ke kino.


Ma hea e kūʻai ai iā Lorcaserin a me kāna mau waena?

Hiki iā ʻoe ke kūʻai i kahi lorcaserin e kūʻai ai ma nā hale kūʻai pūnaewele. Loaʻa ka pauka i ka nui no nā mea noiʻi a me nā loiloi. Ke lilo kāu pahuhopu i nā paona keu no ka momona, hiki iā ʻoe ke nānā iā lorcaserin no ke kūʻai aku ma ka pūnaewele. Eia nō naʻe, koi paha ʻoe i kahi kuhikuhi ma muli o nā alakaʻi koʻikoʻi e ka FDA.
Inā ʻoe e ʻimi nei i ka lorcaserin a i ʻole kāna mau waena, pono ʻoe e nānā me CMOAPI no kahi lako kūpono o nā huahana maʻemaʻe. Ua hōʻoia kā mākou mau hui i ka hōʻoia maikaʻi.


E hoʻomaopopo '
  1. ʻO Taylor, J., Dietrich, E., and Powell, J. (2013). Lorcaserin no ka mālama ʻana i ke kaupaona. Diabetes, Metabolic Syndrome, a me ka momona.
  2. Hoy, SM (2013). Lorcaserin: ʻO kahi loiloi o kāna hoʻohana i ka mālama kaumaha kaumaha. Nā lāʻau.
  3. ʻO Hess, R., a me Cross, LB (2013). Ka palekana a me ka pono o Lorcaserin i ka hoʻokele o ka momona. Lapaʻau laepua.
  4. Brashier, DB, Sharma, AK, Dahiya, N., and Singh, SK (2014). Lorcaserin: He lāʻau lapaʻau Antiobesity Novel. Ka Nupepa o Pharmacology & Pharmacotherapeutics.
  5. Chan, EW et al. (2013). Ka maikaʻi a me ka palekana o Lorcaserin i nā mākua Obese: kahi Meta-Analysis o nā 1-Year Randomized Controlled Trials (RCTs) a me ka Narrative Review on Short-Term RCTs. ʻO nā loiloi Obese.
  6. Nigro, SC, Luon, D., and Baker, WL (2013). Lorcaserin: A Novel Serotonin 2C Agonist no ka mālama ʻana i ka momona. ʻO ka noiʻi noiʻi olakino o kēia manawa a me ka manaʻo.